FDA OKs using viruses to fight Listeria in meat

first_imgAug 22, 2006 (CIDRAP News) – US health officials broke new ground last week by approving the use of a mixture of bacteriophages, or bacteria-killing viruses, to control the pathogen Listeria monocytogenes on ready-to-eat (RTE) meat and poultry products.The Food and Drug Administration (FDA) concluded that a mixture of six bacteriophages developed by Intralytix, Inc., Baltimore, is safe to use. The product, called LMP 102, is the first bacteriophage preparation approved for use as a food additive.The product is intended to be sprayed on RTE meats such as sliced ham and turkey. Each of the bacteriophages in it targets various L monocytogenes strains, and the use of six different phages is intended to reduce the risk that Listeria would develop resistance, according to the FDA record of its decision on the product.Phages infect only bacteria and are part of the normal microbial population of the human intestinal tract, according to the FDA. L monocytogenes can grow at refrigerator temperatures and can cause serious illness, particularly in pregnant women, newborns, and people with weak immunity.The phages in LMP 102 are grown in Listeria cultures, the FDA said. In examining the product’s safety, the agency looked at whether it contains any potentially harmful Listeria residues, particularly one called Listeriolysin O (LLO). Investigators did not detect LLO in the product, and mechanisms in the gut would be likely to inactivate any trace amount present.The report also says that some phages can serve to transfer toxin or drug-resistance genes between bacterial cells, but the phages used in LMP 102 are not that kind.The FDA document does not say exactly how effective the product is in reducing Listeria on RTE meats. But John Vazzana, president and CEO of Intralytix, said that in company tests, LMP 102 has reduced Listeria by 99% to 99.9% (2 to 3 logs) on foods with relatively high levels of contamination.”We concluded from those tests that we could basically get rid of 99% of any LM [L monocytogenes] that’s present,” Vazzana told CIDRAP News.He said Intralytix has licensed the product to a multinational company that serves the food processing industry, but declined to name it. “I would think we’re probably 6 months away from the product being used commercially,” he said.The FDA said its action signals only that the product meets the safety standards of the Federal Food, Drug, and Cosmetic Act. The product must also comply with meat and poultry inspection laws that are administered by the US Department of Agriculture (USDA), which require that food additives be “suitable” for their intended use, the agency said.Vazzana said the USDA has been “actively involved” in the FDA review of LMP 102 and that USDA approval is not in doubt. “This is not new to them; they’ve reviewed the petition, they’ve approved the product,” he said.The USDA will be developing guidelines for use of the product, “and that’s a process we’ll be going through over the next several weeks,” he added.Vazzana said the product may have to be listed on food labels, depending on what the USDA decides. He said that shouldn’t scare consumers, given that phages are “the most ubiquitious organisms on the planet today.””I think what we have to communicate to the consumer is that this is an all-natural approach” and that it will affect only Listeria, he said. “We believe this is a much better solution to a serious problem than using hordes of chemicals.”Vazzana estimated that using LMP 102 will add less than a penny a pound to the cost of RTE meat and poultry products.Food safety expert Craig Hedberg, PhD, said he agreed with the FDA that LMP 102 is likely to be safe, but he was cautious in assessing its likely contribution to controlling Listeria. Hedberg is an associate professor of environmental and occupational health at the University of Minnesota School of Public Health in Minneapolis.”Theoretically, phages make a nice control measure, but the real-world application of these products almost always falls short of the ideal situation,” he told CIDRAP News by e-mail.”This seems to be another tool in the toolkit to control Listeria,” he added. “As such, it gives producers a greater range of options on control. The key to Listeria control is the successful integration of the various tools and careful monitoring of the systems to make sure everything is working as it should.”See also:FDA decision record on LMP 102http://www.fda.gov/OHRMS/DOCKETS/98fr/cf0559.pdflast_img read more

AREC 2018 Gold Coast: The best thing Tinder can teach you about the future

first_imgSteve Carroll of REA Group says immediacy and personalisation are key to future success.TINDER might be revolutionising relationships but swiping right can teach you a whole lot more professionally, according to experts. Steve Carroll of REA Group told the AREC 2018 conference on the Gold Coast that those who stood out mastered the art of personalisation.“There are three million Australians on Tinder. Why, apart from obvious reasons? Because they want to personalise the perfect partner,” he said. MORE FROM AREC 2018: The power of first impression How to be a millionaire agent in 3 years Meet the man behind John McGrath’s success Preparation and urgency are key Mindset is the key to success Australia’s real estate “golden triangle” More from newsParks and wildlife the new lust-haves post coronavirus18 hours agoNoosa’s best beachfront penthouse is about to hit the market18 hours ago“When I was single I would put shades on, go to nightclub and dance weirdly … But the world has moved on. “Nike has augmented reality that allows you to design your own trainers. “Not to be outdone Adidas a few months ago at the Boston Marathon put a widget in 30,000 runners’ vest which enabled them to give every runner a personalised video of their experience within two hours of their run finishing. What do you think these runners did when they got back home? They shared it on Facebook etc with Adidas on it.” Video Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 0:30Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:30 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD432p432p288p288p180p180pAutoA, selectedAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenAREC 2018 promo video00:30 He said there were great opportunities available for those who personalised their services given the way customers had changed and the fact that less than a quarter of the real estate industry was doing so.Brisbane-based Place Estate Agents director Sarah Hackett said her firm redesigned their website and social media to meet the challenge.“Why are we as real estate agents holding back information to get more enquiries. At Place we realised we were not very good at this. So we redesigned our site … What are you doing on your website right now to address immediacy?” FOLLOW SOPHIE FOSTER ON FACEBOOKlast_img read more

100 days later: Premier League returns after coronavirus exile

first_imgManchester City headline the Premier League’s relaunch on WednesdayLondon, United Kingdom | AFP | The Premier League makes its eagerly anticipated return on Wednesday after 100 days in lockdown, with Manchester City’s clash against Arsenal taking centre stage at the start of a frenetic dash to finish the season.While the coronavirus pandemic means the Premier League will look very different from three months ago, football-starved fans will be able to feast on 92 games crammed into less than six weeks.There is still much to decide over the rest of the season, with Liverpool on the brink of their first English title for 30 years, Champions League places up for grabs and a heated relegation battle going down to the wire.Relegation-threatened Aston Villa get the ball rolling on Wednesday with their home game against European hopefuls Sheffield United.Pep Guardiola’s second-placed City provide the star power when Arsenal visit the Etihad Stadium a few hours later.A City defeat would mean leaders Liverpool would clinch the title if they won at Merseyside rivals Everton on Sunday.It was the announcement that Arsenal manager Mikel Arteta had contracted the virus in March that forced the Premier League to press pause.With all games being played behind closed doors, players will have to get used to the eerie silence in the usually noisy stands.Piping crowd chants into stadiums, cardboard cut-outs of supporters and live video fan walls will add colour but the absence of fans will be a jarring sight at first.In total, about 300 people will be allowed in stadiums for each match, with strict health protocols in place.There will be widespread disinfection of changing facilities, dugouts, matchballs, goalposts, corner flags and substitution boards.People other than players and coaching staff on team benches must wear face coverings.Players have been told to maintain social-distancing during goal celebrations and encouraged not to spit.– ‘A little bit weird’ – Share on: WhatsApp Having followed the return of Germany’s Bundesliga and La Liga in Spain, City manager Pep Guardiola is well aware what an unusual experience it will be.“It was a little bit weird watching the games,” he said. “When you play at home you have that extra intensity and passion from the crowd. That is not going to happen.“But when the players were little kids they played in the streets without spectators and they played good. That is what they have to do. It is a football game. Try to follow what they know.”Concerned that the hectic schedule will impact his players’ fitness and the quality of their performances, Guardiola added: “The problem is not to play one game, it is to play another and another with a lack of physical training to be prepared.“They had six weeks (to prepare) in Germany, double what we had, and five weeks in Spain.“We have to adapt as quick as possible. In terms of the rhythm, if teams don’t rotate their performance goes down immediately. There will be a lot of ups and downs in the games.”The Premier League’s rush to finish the season has drawn criticism from some clubs and players, including City stars Sergio Aguero and Raheem Sterling.With England so badly hit by the pandemic and Guardiola’s own mother dying of the virus in Spain, the City boss was asked if he had doubts about whether the Premier League should return now.“Sometimes,” he said. “I understand we have to do it. Always you had the feeling the damage for the clubs was huge. You have to do it to reduce the impact as much as possible.“We were in contact with the doctors, the scientists. They allowed us to play so of course we do it.“But overall the health of the people (is most important). Nobody wants to die because they are contaminated. The social distance, the mask, the hand sanitiser.“We have to stay alert because the virus is still there.”last_img read more